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reverse tolerance
Reverse tolerance or drug sensitization is the phenomenon of a reversal of the side-effects from a drug, the reduction of insensitivity caused after drug tolerance has been established, or, in some cases, an increase in specific effects of a single drug existing alongside a tolerance to other effects of the same substance.〔(Cross reverse tolerance between amphetamine, cocaine and morphine. )〕〔(Drugs & Death : Profiles of illegal drug abuse. Joseph C. Rupp, M.D., Ph.D. )〕 Typically this involves the use of additional medication or abstinence from a drug for a period of time, known as a drug holiday. Such drugs include amphetamines and SSRIs.
As a result, regular users commonly experience a quick decrease of unwanted side effects, without an equivalent loss of its stimulant properties.
==See also==
*Desensitization (medicine)
*Downregulation and upregulation
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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